Tirzepatide (Zepbound, Mounjaro) is used for weight loss and type 2 diabetes in adults. Tirzepatide is a GIP and GLP-1 receptor agonist and works for weight loss by decreasing your appetite and slowing the movement of food from the stomach into the small intestine, which may make you feel full more quickly and for a longer period of time. Tirzepatide also decreases blood sugar levels by increasing insulin production and lowering the amount of sugar the liver makes.
Zepbound is FDA-approved for weight loss for adults with obesity or who are overweight and have weight-related medical problems. Zepbound helps you to lose weight and maintain weight loss and should be combined with diet and exercise.
Mounjaro is used to help lower blood sugar for adults with type 2 diabetes; it should be used together with diet and exercise.
Mounjaro and Zepbound both contain the same active ingredient, tirzepatide and are made by Eli Lilly and Company. They are both given as weekly injections under the skin and are available as single-dose pens in the same strengths 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg,15 mg per 0.5 mL.
Tirzepatide is a GIP and GLP-1 receptor agonist, so it works (mechanism of action) by activating both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. GLP-1 helps control appetite and calorie intake, and GIP is thought to contribute to regulating food intake as well.
Tirzepatide (Mounjaro) can be used as a single therapy (on its own) or with other diabetes medicines, including sulfonylureas, SGLT2 inhibitors or metformin.
It is not known if Tirzepatide can be used in people who have had pancreatitis. Tirzepatide should not be used in people who have type 1 diabetes.
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